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Muscarinic (M3) receptors are present onvascular endothelial cells: vasodilatation isprimarily mediated through the release of anendothelium dependent relaxing factor (EDRF)which is nitric oxide (NO). While MVimproves delivery of oxygen to the lungs, under anesthesia, this oxygen is saturated withinhalant, which results in inadvertent “overdosing” of a patient and worsening contractil-ity
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