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p53 regulates the expression of miR107, which can target the bindingpartner of HIF1?, HIF1?, leading to decreased hypoxic gene expression.Overexpression of this miR in mice suppresses VEGF expression and angiogenesis,and in tumours its expression inversely correlates with HIF1? [ 54 ]. It was offered as an alternative to performing a Brooke end ileostomy forpatients who underwent total colectomies for a variety of diagnoses, most commonlyinflammatory bowel disease.1,2 The Parks’ procedure offered important advantages overthe previously used ileoanal end-to-end anastomosis (without a pouch reservoir), whichresulted in poor functional outcomes, including higher fecal frequency, urgency, andincontinence rates.3-5 With the addition of a pouch that serves as a lower pressurereservoir, patients are offered the quality-of-life advantage of restoring the continuity oftheir intestinal tracts, which obviates the need for permanent abdominal wall stomas (andostomy appliances). In addition, Clara cells producea 16 kDa protein known as Clara cell secretory pro-tein (CC16), which is an abundant component of theairway secretion

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